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Article

Autophagy promotes oligodendrocyte survival and function following dysmyelination in a long-lived myelin mutant.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 2013

Smith Chelsey M, Mayer Joshua A, Duncan Ian D

Abstract excerpt

The Long-Evans shaker (les) rat has a mutation in myelin basic protein that results in severe CNS dysmyelination and subsequent demyelination during development. During this time, les oligodendrocytes accumulate cytoplasmic vesicles, including lysosomes and membrane-bound organelles. However, the mechanism and functional relevance behind these oligodendrocyte abnormalities in les have not been investigated. Using...

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Identifiers

PMID: 23637198
DOI: 10.1523/JNEUROSCI.0233-13.2013
PMCID: PMC4128639

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