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Article

Mutations in the rat myelin basic protein gene are associated with specific alterations in other myelin gene expression.

Neuroscience letters - 13 Sept 2002

Carré Jean-Luc, Goetz Brian D, O'Connor Lawrence T, Bremer Quentin, Duncan Ian D

Abstract excerpt

The Long Evans shaker (les) rat is a myelin basic protein (MBP) mutant that exhibits severe central nervous system (CNS) dysmyelination. We used a combination of immunohistochemistry, immunoblot and Northern blot analyses to determine the effect of MBP deficits on the expression of other CNS myelin genes in this mutant. Immunohistochemistry revealed a marked reduction in all major myelin proteins and differences...

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Source

Identifiers

PMID: 12213624
DOI: 10.1016/s0304-3940(02)00709-7

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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