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Article

Enhanced epileptogenic susceptibility in a genetic model of reactive synaptogenesis: the spastic Han-Wistar rat.

Developmental neuroscience - 1 Jan 2002

Cepeda Carlos, Crawford Cynthia A, Margulies Jody E, Watson Joseph B, Levine Michael S, Cohen Randy W

Abstract excerpt

Our laboratory has been studying the spastic Han-Wistar (sHW) rat as a model of neuronal degeneration. Mutant sHW rats display a number of developmental abnormalities that eventually lead to hippocampal pyramidal cell death and synaptic reorganization starting around 30 days of age. The present study examined the contribution of hippocampal reorganization to the expression of seizures induced by systemic...

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Identifiers

PMID: 12457064
DOI: 10.1159/000066740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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