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Tembleque (SDtq) rat: A new model of leukodystrophy associated with hypomyelination and impaired oligodendrocyte maturation.

Laboratory animals - 1 Feb 2026

Breijo Martín, Fontes Florencia, Santos Mariela, Martínez Palma Laura, Rocha Sergio, Genovesse Patricia, Liu Bin, Aghado David, Perez Carlos, Benavides Fernando

Abstract excerpt

This work presents the characterization of tembleque (SDtq) rats as a novel animal model for myelination abnormalities, primarily manifesting as tremors and ataxia, which notably declined by 16 weeks of age. This model originated from a spontaneous autosomal recessive mutation in an outbred Sprague Dawley colony. Histological and electron microscopy analyses revealed significant hypomyelination in the central...

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PMID: 41914324
DOI: 10.1177/00236772251369173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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