Article
Hsp70 family molecular chaperones and mutant insulin receptor: differential binding specificities of BiP and Hsp70/Hsc70 determines accumulation or degradation of insulin receptor.
Biochemical and biophysical research communications - 17 Jan 1996
Sawa T, Imamura T, Haruta T, Sasaoka T, Ishiki M, Takata Y, Takada Y, Morioka H, Ishihara H, Usui I, Kobayashi M
Abstract excerpt
We have examined the binding specificities of Hsp70 family molecular chaperones, BiP and Hsp70/Hsc70, to wild-type or mutant insulin receptors. BiP bound to proreceptor of wild-type insulin receptor, but not to mature receptor. A mutant insulin receptor, which lacked 47 amino acid residues (delta Ex13 IR) corresponding to exon 13 of insulin receptor gene, accumulated in the endoplasmic reticulum as uncleaved...
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