Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of unprocessed insulin proreceptors in COS 7 cells transfected with cDNA with Arg735----Ser735 point mutation at the cleavage site.

Metabolism: clinical and experimental - 1 Aug 1992

Sugibayashi M, Shigeta Y, Teraoka H, Kobayashi M

Abstract excerpt

We previously reported on patients with severe insulin resistance due to unprocessed insulin proreceptors. A structural change of the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Arg-Ser due to G----T point mutation appeared to be the cause for failure to process the proreceptors. To determine whether the mutation of insulin proreceptors at the cleavage site was responsible for unprocessed insulin receptors and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Northern

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line

Share to Molecular Sequence Data

Share to Mutation

Share to Phosphorylation

Share to Transfection

Source

Identifiers

PMID: 1640858
DOI: 10.1016/0026-0495(92)90161-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of unprocessed insulin proreceptors in COS 7 cells transfected with cDNA with Arg735----Ser735 point mutation at the cleavage site.PMID 1640858Read ↗

Transfection of cDNA with G----T point mutation at the cleavage site of insulin receptors to COS 7 cells.Semantic proximity Read ↗

Characterization of an insulin receptor mutant lacking the subunit processing site.Semantic proximity Read ↗

Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity.Semantic proximity Read ↗

Leu 193 mutation in the cysteine rich region of the insulin receptor inhibits the cleavage of the insulin receptor precursor but not insulin binding.Semantic proximity Read ↗

Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells.Semantic proximity Read ↗

Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor.Semantic proximity Read ↗

A leucine to proline mutation at position 233 in the insulin receptor inhibits cleavage of the proreceptor and transport to the cell surface.Semantic proximity Read ↗

Immunoglobulin heavy chain-binding protein binds to misfolded mutant insulin receptors with mutations in the extracellular domain.Semantic proximity Read ↗

Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor.Semantic proximity Read ↗

Postbinding characterization of five naturally occurring mutations in the human insulin receptor gene: impaired insulin-stimulated c-jun expression and thymidine incorporation despite normal receptor autophosphorylation.Semantic proximity Read ↗

Deletion of C-terminal 113 amino acids impairs processing and internalization of human insulin receptor: comparison of receptors expressed in CHO and NIH-3T3 cells.Semantic proximity Read ↗

Mutational analysis of the N-linked glycosylation sites of the human insulin receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.