Article

The Small Tumor Antigen of Merkel Cell Polyomavirus Accomplishes Cellular Transformation by Uniquely Localizing to the Nucleus Despite the Absence of a Known Nuclear Localization Signal

2023-11-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Merkel Cell Carcinoma (MCC) is an aggressive skin cancer that is three times deadlier than melanoma. In 2008, it was found that 80% of MCC cases are caused by the genomic integration of a novel polyomavirus, Merkel Cell Polyomavirus (MCPyV), and the expression of its small and truncated large tumor antigens (ST and LT-t, respectively). MCPyV belongs to a family of human poly...

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Literature Corpus work: 963b9c5b-7226-5350-9614-26c49876baac
DOI: 10.1101/2023.11.28.569067

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