Article
An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype.
British journal of clinical pharmacology - 1 Oct 1995
Panserat S, Mura C, Gérard N, Vincent-Viry M, Galteau M M, Jacoz-Aigrain E, Krishnamoorthy R
Abstract excerpt
1. The study of the CYP2D genotype and phenotype of a Caucasian family revealed that a XbaI-9 kb allele was associated with the poor metabolizer phenotype. 2. A Polymerase Chain Reaction (PCR)-based assay showed that the previously described mutations D6A and D6B are not associated with the XbaI-9 kb allele. 3. To explore the molecular basis of the poor metabolizer phenotype associated with the XbaI-9 kb allele,...
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