Article
Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.
Molecular pharmacology - 1 Sept 1994
Johansson I, Oscarson M, Yue Q Y, Bertilsson L, Sjöqvist F, Ingelman-Sundberg M
Abstract excerpt
Cytochrome P4502D6 (CYP2D6) catalyzes the oxidative metabolism of several clinically important classes of drugs. Many of these have lower metabolic clearance rates among Chinese, compared with Caucasians, and are prescribed at lower doses for Asian patients. We have now evaluated the molecular ge...
Topics
- Asian People
- Base Sequence
- Cells, Cultured
- Chimera
- China
- Chloramphenicol O-Acetyltransferase
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Gene Expression Regulation, Enzymologic
- Haplotypes
- Humans
- Hydroxylation
- Mixed Function Oxygenases