Article
An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution.
Human genetics - 1 Mar 1995
Daly A K, Leathart J B, London S J, Idle J R
Abstract excerpt
The cytochrome P450 CYP2D6 is a polymorphic enzyme, for which 5%-10% of Caucasians (poor metabolizers) lack activity. The majority of mutations giving rise to the deficiency have now been identified but some individuals show anomalous phenotype-genotype relationships when screened for the common...
Topics
- Adult
- Base Sequence
- Case-Control Studies
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA Mutational Analysis
- DNA Primers
- Debrisoquin
- Genes
- Genotype
- Heterozygote
- Humans
- Male
- Mixed Function Oxygenases
- Molecular Sequence Data
- Phenotype
- Point Mutation
- Sequence Deletion