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Article

The cellular HIV-1 Rev cofactor hRIP is required for viral replication.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2005

Yu Zhong, Sánchez-Velar Nuria, Catrina Irina E, Kittler Ellen L W, Udofia Enyeneama B, Zapp Maria L

Abstract excerpt

An important goal of contemporary HIV type 1 (HIV-1) research is to identify cellular cofactors required for viral replication. The HIV-1 Rev protein facilitates the cytoplasmic accumulation of the intron-containing viral gag-pol and env mRNAs and is required for viral replication. We have previously shown that a cellular protein, human Rev-interacting protein (hRIP), is an essential Rev cofactor that promotes...

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Identifiers

PMID: 15749819
DOI: 10.1073/pnas.0408889102
PMCID: PMC552779

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