Article
Homozygous deletion map at 18q21.1 in pancreatic cancer.
Cancer research - 1 Feb 1996
Hahn S A, Hoque A T, Moskaluk C A, da Costa L T, Schutte M, Rozenblum E, Seymour A B, Weinstein C L, Yeo C J, Hruban R H, Kern S E
Abstract excerpt
Absolute genetic differences between neoplastic and nonneoplastic cells can be discerned at sites of homozygous deletions. These deletions are of critical interest because they might be useful in the identification of defective biochemical pathways in neoplastic cells, and subsequently for the de...
Topics
- Alleles
- Base Sequence
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Chromosomes, Human, Pair 18
- Cloning, Molecular
- Cosmids
- Gene Deletion
- Genes, Tumor Suppressor
- Homozygote
- Humans
- Molecular Sequence Data