Article
Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation.
Genes, chromosomes & cancer - 1 Jul 1999
Ried T, Heselmeyer-Haddad K, Blegen H, Schröck E, Auer G
Abstract excerpt
The transition of normal epithelium to invasive carcinoma occurs sequentially. In colorectal and cervical carcinogenesis, this transition is reflected by histomorphologically defined grades of increasing dysplasia that untreated may progress to invasive disease. In an attempt to understand the role of chromosomal aberrations during tumorigenesis we have applied comparative genomic hybridization using DNA...
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