Transition of high‐grade cervical intraepithelial neoplasia to micro‐invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities

Abstract excerpt

Cervical intraepithelial neoplasia (CIN I, II, and III) and cases of CIN III associated with micro-invasive cervical carcinoma (CIN III & mCA) were analysed for evidence of episomal or integrated human papillomavirus (HPV) 16/18 DNA by fluorescence in situ hybridization (FISH). In parallel, numerical aberrations of chromosomes 1, 17, and X were determined in these lesions as indicators of genomic instability. HPV...

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