Genomic integration of oncogenic HPV and gain of the human telomerase gene <i>TERC</i> at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer

Abstract excerpt

Recently proposed events associated with the progression of cervical intraepithelial neoplasia (CIN) 2/3 to cervical carcinoma include integration of human papillomavirus (HPV) into the host genome, genomic instability, and an increase in chromosome 3q copy number. In particular, the gene coding for the RNA component of telomerase (TERC) at 3q26 has been implicated as a possible candidate gene. Since it is not...

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