Article
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
The EMBO journal - 1 Sept 1991
Elledge S J, Spottswood M R
Abstract excerpt
The onset of S-phase and M-phase in both Schizosaccharomyces pombe and Saccharomyces cerevisiae requires the function of the cdc2/CDC28 gene product, p34, a serine-threonine protein kinase. A human homolog, p34cdc2, was identified by functional complementation of the S.pombe cdc2 mutation (Lee and Nurse, 1987). Using a human cDNA expression library to search for suppressors of cdc28 mutations in S. cerevisiae, we...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- CDC2 Protein Kinase
- CDC2-CDC28 Kinases
- Cell Cycle
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases
- DNA, Fungal
- Fungal Proteins