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Article

Relationships between cytoprotection and mutation prevention by WR-1065.

Military medicine - 1 Feb 2002

Grdina David J, Murley Jeffrey S, Kataoka Yasushi, Epperly William

Abstract excerpt

WR-2721, the leading compound that has emerged from the U.S. Army's Drug Synthesis and Development Program, has become the first clinically used cytoprotector in cancer therapy. The ability of its active thiol, WR-1065, to act as an antioxidant to scavenge free radicals, donate hydrogen atoms, and induce auto-oxidation is related to its cytoprotective effectiveness. However, at concentrations 10 to 20 times lower...

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PMID: 11873516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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