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Article

Characterization of a transport and detoxification pathway for the antitumour drug bleomycin in Saccharomyces cerevisiae.

The Biochemical journal - 15 Nov 2004

Aouida Mustapha, Leduc Anick, Wang Huijie, Ramotar Dindial

Abstract excerpt

BLM (bleomycin) is effective in combination therapy against various cancers including testicular cancer. However, several other cancers such as colon cancer are refractory to BLM treatment. The exact mechanism for this differential response of cancer cells to the drug is not known. In the present study, we created fluorescently labelled BLM-A5, which retained nearly full genotoxic potential, and used this...

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Source

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Identifiers

PMID: 15248838
DOI: 10.1042/BJ20040392
PMCID: PMC1134087

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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