Hprt mutations in human T-lymphocytes reflect radioprotective effects of the aminothiol, WR-1065.

doi:10.1093/carcin/17.12.2647

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Article

Hprt mutations in human T-lymphocytes reflect radioprotective effects of the aminothiol, WR-1065.

Carcinogenesis - 1 Dec 1996

Clark L S, Albertini R J, Nicklas J A

Abstract excerpt

Aminothiols such as WR-2721 and its active free thiol WR-1065 have previously been shown to reduce mutations resulting from ionizing radiation in exponentially growing cells. In this study, non-dividing human G0 T-lymphocytes were exposed to the aminothiol radioprotective agent, WR-1065, 30 min b...

Topics

Antimutagenic Agents
Cell Cycle
Humans
Hypoxanthine Phosphoribosyltransferase
Mercaptoethylamines
Mutation
Radiation-Protective Agents
T-Lymphocytes

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