Genetic changes and bioassays in bleomycin- and phleomycin-treated cells, and their relationship to chromosomal breaks.

doi:10.1016/0921-8777(94)00040-d

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Article

Genetic changes and bioassays in bleomycin- and phleomycin-treated cells, and their relationship to chromosomal breaks.

Mutation research - 1 Jan 1995

Koy J F, Pleninger P, Wall L, Pramanik A, Martinez M, Moore C W

Abstract excerpt

The recombinogenicity of damaged chromosomes in diploid Saccharomyces cerevisiae cells treated with bleomycin and structurally related phleomycin was measured, along with aneuploidy and mutation events. Phleomycin was substantially (up to 26-fold) more effective than bleomycin in producing geneti...

Topics

Aneuploidy
Bleomycin
Cell-Free System
Chromosomes, Fungal
DNA Damage
DNA, Fungal
Mitosis
Mutation
Phleomycins
Saccharomyces cerevisiae
Time Factors

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