Article
DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication.
Genes & development - 1 May 1997
Campbell K S, Mullane K P, Aksoy I A, Stubdal H, Zalvide J, Pipas J M, Silver P A, Roberts T M, Schaffhausen B S, DeCaprio J A
Abstract excerpt
The amino-terminal domain of SV40 large tumor antigen (TAg) is required for efficient viral DNA replication. However, the biochemical activity associated with this domain has remained obscure. We show here that the amino-terminal domain of TAg shares functional homology with the J-domain of DnaJ/...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Polyomavirus Transforming
- Base Sequence
- Carrier Proteins
- Cell Line
- DNA Primers
- DNA Replication
- Escherichia coli Proteins
- HSC70 Heat-Shock Proteins
- HSP40 Heat-Shock Proteins
- HSP70 Heat-Shock Proteins
- Heat-Shock Proteins
- Humans