Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The J Domain of Simian Virus 40 Large T Antigen Is Required To Functionally Inactivate RB Family Proteins

1 Mar 1998

Abstract excerpt

Transformation by simian virus 40 large T antigen (TAg) is dependent on the inactivation of cellular tumor suppressors. Transformation minimally requires the following three domains: (i) a C-terminal domain that mediates binding to p53; (ii) the LXCXE domain (residues 103 to 107), necessary for binding to the retinoblastoma tumor suppressor protein, pRB, and the related p107 and p130; and (iii) an N-terminal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunotherapy and Immune Responses
Share to Polyomavirus and related diseases
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9488456
DOI: 10.1128/mcb.18.3.1408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The J Domain of Simian Virus 40 Large T Antigen Is Required To Functionally Inactivate RB Family ProteinsPMID 9488456Read ↗

Inactivation of pRB-Related Proteins p130 and p107 Mediated by the J Domain of Simian Virus 40 Large T AntigenSemantic proximity Read ↗

Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation.Semantic proximity Read ↗

SV40 large T antigen promotes dephosphorylation of p130.Semantic proximity Read ↗

The SV40 Large T Antigen Contains a Decoy Phosphodegron That Mediates Its Interactions with Fbw7/hCdc4Semantic proximity Read ↗

Novel Mechanisms of E2F Induction by BK Virus Large-T Antigen: Requirement of Both the pRb-Binding and the J DomainsSemantic proximity Read ↗

The Retinoblastoma Protein Is Required for Ras-Induced Oncogenic TransformationSemantic proximity Read ↗

pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent EpitheliaSemantic proximity Read ↗

Understanding the targeting of the RB family proteins by viral oncoproteins to defeat their oncogenic machinerySemantic proximity Read ↗

The amino-terminal region of SV40 large T antigen is sufficient to induce hepatic tumours in mice.Semantic proximity Read ↗

JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.Semantic proximity Read ↗

SV40 17KT antigen complements dnaj mutations in large T antigen to restore transformation of primary human fibroblasts.Semantic proximity Read ↗

The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.