Article
Interaction between T antigen and TEA domain of the factor TEF-1 derepresses simian virus 40 late promoter in vitro: identification of T-antigen domains important for transcription control.
Journal of virology - 1 Feb 1996
Berger L C, Smith D B, Davidson I, Hwang J J, Fanning E, Wildeman A G
Abstract excerpt
The large tumor antigen (TAg) of simian virus 40 regulates transcription of the viral genes. The early promoter is repressed when TAg binds to the origin and DNA replication begins, whereas the late promoter is activated by TAg through both replication-dependent and -independent mechanisms. Previ...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Base Sequence
- Binding Sites
- DNA, Viral
- DNA-Binding Proteins
- Gene Expression Regulation, Viral
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- TEA Domain Transcription Factors