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Article

MYC levels govern hematopoietic tumor type and latency in transgenic mice.

Blood - 15 Jul 2006

Smith Darrin P, Bath Mary L, Metcalf Donald, Harris Alan W, Cory Suzanne

Abstract excerpt

Deregulated MYC expression has been implicated in the etiology of many human cancers, including hematopoietic malignancies. To explore the impact of widespread constitutive MYC expression in the hematopoietic compartment, we have used a vector containing regulatory elements of the Vav gene to generate transgenic mice. VavP-MYC mice are highly tumor-prone and the level of MYC was found to influence both the...

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Topics

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Share to Hematologic Neoplasms
Share to Hematopoietic Stem Cells
Share to Leukemia, Myeloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, T-Cell

Share to Macrophage Colony-Stimulating Factor

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

Share to Proto-Oncogene Proteins c-vav

Source

Open in PubMed Open full text

Identifiers

PMID: 16537801
DOI: 10.1182/blood-2006-01-0172
PMCID: PMC1895495

Genes

MYC
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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