Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis.

Oncogene - 27 May 2004

Parghi Sean S, Brandvold Kimberly A, Bowers Sandra J, Neiman Paul E, Ruddell Alanna

Abstract excerpt

Avian leukosis virus (ALV) induces bursal lymphoma in tumor-susceptible chicken strains after proviral integration within the c-myc gene, and subsequent expansion of Myc-overexpressing lymphocytes within transformed follicles. Line 6(3) strain chickens are resistant to ALV tumorigenesis, largely failing to develop Myc-transformed follicles, although they show similar levels of ALV infection and integration as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, B-Lymphocyte
Share to Avian Leukosis Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Transformation, Viral

Share to Genes, myc

Share to Proto-Oncogene Proteins c-myc

Share to Proviruses

Share to Terminal Repeat Sequences

Share to Virus Integration

Source

Identifiers

PMID: 15064748
DOI: 10.1038/sj.onc.1207577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis.PMID 15064748Read ↗

GADD45β, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens.Semantic proximity Read ↗

Marek's Disease Virus-Encoded MicroRNA 155 Ortholog Critical for the Induction of Lymphomas Is Not Essential for the Proliferation of Transformed Cell LinesSemantic proximity Read ↗

Growth retardation induced by avian leukosis virus subgroup J associated with down-regulated Wnt/β-catenin pathway.Semantic proximity Read ↗

Pathogenesis of a Marek's disease virus mutant lacking vIL-8 in resistant and susceptible chickens.Semantic proximity Read ↗

A review of the development of chicken lines to resolve genes determining resistance to diseases.Semantic proximity Read ↗

MicroRNA-26a-mediated regulation of interleukin-2 expression in transformed avian lymphocyte linesSemantic proximity Read ↗

Functional genomic analysis reveals distinct neoplastic phenotypes associated with c-myb mutation in the bursa of Fabricius.Semantic proximity Read ↗

The long view: 40 years of avian leukosis researchSemantic proximity Read ↗

Homodimerization of the Meq Viral Oncoprotein Is Necessary for Induction of T-Cell Lymphoma by Marek's Disease VirusSemantic proximity Read ↗

Neoplastic transformation and tumorigenesis by the human protooncogene MYC.Semantic proximity Read ↗

The v-rel oncogene of avian reticuloendotheliosis virus transforms immature and mature lymphoid cells of the B cell lineage in vitro.Semantic proximity Read ↗

Acquisition of resistance to avian leukosis virus subgroup B through mutations on tvb cysteine-rich domains in DF-1 chicken fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.