Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.

doi:10.1084/jem.183.1.329

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Article

Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.

The Journal of experimental medicine - 1 Jan 1996

Benatar T, Carsetti R, Furlonger C, Kamalia N, Mak T, Paige C J

Abstract excerpt

CD45 expression is essential for immunoglobulin (Ig)-mediated B cell activation. Treatments with either anti-Ig or anti-CD45 suggest that CD45 may facilitate early signaling events such as calcium mobilization, and phosphoinositide hydrolyis as well as later events leading to transcription of gen...

Topics

Animals
Antigens, CD
B-Lymphocytes
Blotting, Western
CD79 Antigens
Calcium
Enzyme Activation
Flow Cytometry
Immunoglobulin M
Isoenzymes
Leukocyte Common Antigens
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Mice, Mutant Strains

Phenotype

Phospholipase C gamma

Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 8551241
DOI: 10.1084/jem.183.1.329
PMCID: PMC2192424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8551241-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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