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Article

Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.

The Journal of experimental medicine - 1 Jan 1996

Benatar T, Carsetti R, Furlonger C, Kamalia N, Mak T, Paige C J

Abstract excerpt

CD45 expression is essential for immunoglobulin (Ig)-mediated B cell activation. Treatments with either anti-Ig or anti-CD45 suggest that CD45 may facilitate early signaling events such as calcium mobilization, and phosphoinositide hydrolyis as well as later events leading to transcription of genes such as c-myc. To examine the role of CD45 more extensively, CD45-deficient mice were generated by disruption of...

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Identifiers

PMID: 8551241
DOI: 10.1084/jem.183.1.329
PMCID: PMC2192424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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