Article
CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells.
Science (New York, N.Y.) - 13 Dec 1996
Bikah G, Carey J, Ciallella J R, Tarakhovsky A, Bondada S
Abstract excerpt
A subset of B lymphocytes present primarily in the peritoneal and pleural cavities is defined by the expression of CD5 and is elevated in autoimmune diseases. Upon signaling through membrane immunoglobulin M (mIgM), splenic B lymphocytes (B-2) proliferate, whereas peritoneal B cells (B-1) undergo...
Topics
- Animals
- Apoptosis
- B-Lymphocyte Subsets
- CD5 Antigens
- Calcium
- Cell Division
- Cell Nucleus
- Cross-Linking Reagents
- Female
- Immunoglobulin M
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- NF-kappa B
- Peritoneal Cavity
- Receptors, Antigen, B-Cell