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Article

CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells.

Science (New York, N.Y.) - 13 Dec 1996

Bikah G, Carey J, Ciallella J R, Tarakhovsky A, Bondada S

Abstract excerpt

A subset of B lymphocytes present primarily in the peritoneal and pleural cavities is defined by the expression of CD5 and is elevated in autoimmune diseases. Upon signaling through membrane immunoglobulin M (mIgM), splenic B lymphocytes (B-2) proliferate, whereas peritoneal B cells (B-1) undergo apoptosis. However, in CD5-deficient mice, B-1 cells responded to mIgM crosslinking by developing a resistance to...

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Identifiers

PMID: 8943203
DOI: 10.1126/science.274.5294.1906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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