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Article

CD45 recruits adapter protein DOK-1 and negatively regulates JAK-STAT signaling in hematopoietic cells.

Molecular immunology - 1 Jul 2009

Wu Liangtang, Bijian Krikor, Shen Shi-Hsiang, Shen Shi-Shiang

Abstract excerpt

It has been extensively documented that CD45 positively regulates T cell receptor-mediated signaling through the activation of Src-family kinases. The mechanism whereby CD45 negatively regulates the JAK/STAT pathway, however, has not been fully elucidated. Here we describe the mechanism by which CD45 negatively regulates the JAK/STAT pathway through the recruitment of the inhibitory molecule Downstream of Kinase...

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Identifiers

PMID: 19481264
DOI: 10.1016/j.molimm.2009.04.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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