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Article

Mapping the fodrin binding domain in CD45, a leukocyte membrane-associated tyrosine phosphatase.

The Journal of biological chemistry - 18 Nov 1994

Iida N, Lokeshwar V B, Bourguignon L Y

Abstract excerpt

CD45 belongs to a family of high molecular mass leukocyte glycoproteins. It contains both an intrinsic protein tyrosine phosphatase (PTPase) activity and a cytoskeleton binding site in its cytoplasmic domain. Certain cytoskeletal proteins, such as fodrin (a spectrin-like molecule), are known to play an important role in the regulation of CD45's PTPase activity. In this study we mapped the fodrin binding domain of...

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PMID: 7961804

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