Article
Mapping the fodrin binding domain in CD45, a leukocyte membrane-associated tyrosine phosphatase.
The Journal of biological chemistry - 18 Nov 1994
Iida N, Lokeshwar V B, Bourguignon L Y
Abstract excerpt
CD45 belongs to a family of high molecular mass leukocyte glycoproteins. It contains both an intrinsic protein tyrosine phosphatase (PTPase) activity and a cytoskeleton binding site in its cytoplasmic domain. Certain cytoskeletal proteins, such as fodrin (a spectrin-like molecule), are known to p...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Carrier Proteins
- Cell Membrane
- Cytoplasm
- Leukocyte Common Antigens
- Leukocytes
- Mice
- Microfilament Proteins
- Molecular Sequence Data
- Mutation
- Protein Tyrosine Phosphatases
- Sequence Deletion
- Spectrin
- Up-Regulation