Article
Detection of p53 gene alteration in renal-cell cancer by micropreparation techniques of tumor specimens.
International journal of cancer - 20 Dec 1995
Kuczyk M A, Serth J, Bokemeyer C, Jonassen J, Arndt H, Paeslack U, Werner M, Tan H K, Jonas U
Abstract excerpt
Alterations in the p53 tumor-suppressor gene have been identified in a variety of human malignancies, including renal-cell cancer. A technique for the isolation of tumor areas from tissue specimens to analyze formalin-fixed and paraffin-embedded tumors and try to avoid a disturbance of the results due to genetic background signal by the presence of tumor-infiltrating lymphocytes, was established. The presence of...
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