Microdissection as a means to verify allelic imbalance in tumour biology samples.

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Article

Microdissection as a means to verify allelic imbalance in tumour biology samples.

Anticancer research - 1 Jan 2000

Speiser P, Gharehbaghi-Schnell E, Schneeberger C, Eder S, Zeillinger R

Abstract excerpt

Allelotypes (TP53, AFM051xd10 and alu-i1) in normal DNA and in DNA from paraffin-embedded tumours of a patient with a p53 germ-line mutation were compared in order to demonstrate LOH. Microdissection was applied in order to overcome difficulties with the interpretation of LOH data from a pelvic r...

Topics

Alleles
Base Sequence
DNA
DNA, Neoplasm
Dissection
Exons
Gene Deletion
Genes, p53
Heterozygote
Histiocytoma, Benign Fibrous
Humans
Lymphocytes
Male
Middle Aged
Molecular Sequence Data
Mutation
Paraffin Embedding
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 8615654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8615654-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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