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Article

Human Skin Keratinocytes on Sustained TGF-β Stimulation Reveal Partial EMT Features and Weaken Growth Arrest Responses.

Cells - 20 Jan 2020

Liarte Sergio, Bernabé-García Ángel, Nicolás Francisco J

Abstract excerpt

Defects in wound closure can be related to the failure of keratinocytes to re-epithelize. Potential mechanisms driving this impairment comprise unbalanced cytokine signaling, including Transforming Growth Factor-β (TFG-β). Although the etiologies of chronic wound development are known, the relevant molecular events are poorly understood. This lack of insight is a consequence of ethical issues, which limit the...

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Identifiers

PMID: 31968599
DOI: 10.3390/cells9010255
PMCID: PMC7017124

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