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Article

Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.

Breast cancer research : BCR - 1 Jan 2004

Brown Kimberly A, Aakre Mary E, Gorska Agnieska E, Price James O, Eltom Sakina E, Pietenpol Jennifer A, Moses Harold L

Abstract excerpt

INTRODUCTION: Transforming growth factor (TGF)-beta1 is proposed to inhibit the growth of epithelial cells in early tumorigenesis, and to promote tumor cell motility and invasion in the later stages of carcinogenesis through the induction of an epithelial to mesenchymal transition (EMT). EMT is a multistep process that is characterized by changes in cell morphology and dissociation of cell-cell contacts. Although...

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Identifiers

PMID: 15084245
DOI: 10.1186/bcr778
PMCID: PMC400675

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Source receipt: pubmed, retrieved 7 Sept 2026.

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