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Article

A conditional mouse model for measuring the frequency of homologous recombination events in vivo in the absence of essential genes.

Molecular and cellular biology - 1 Sept 2011

Brown Adam D, Claybon Alison B, Bishop Alexander J R

Abstract excerpt

The ability to detect and repair DNA damage is crucial to the prevention of various diseases. Loss of function of genes involved in these processes is known to result in significant developmental defects and/or predisposition to cancer. One such DNA repair mechanism, homologous recombination, has the capacity to repair a wide variety of lesions. Knockout mouse models of genes thought to be involved in DNA repair...

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Identifiers

PMID: 21709021
DOI: 10.1128/MCB.00848-10
PMCID: PMC3165555

Genes

BLM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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