Article
The induction of dominant somatic mutations at the Dlb-1 locus.
Mutation research - 1 Feb 1995
Cosentino L, Heddle J A
Abstract excerpt
In the small intestine of heterozygous mice (Dlb-1b/Dlb-1a), the Dlb-1b allele results in a stainable epithelium. The mutation or loss of the dominant Dlb-1b allele in a stem cell results in a non-staining ribbon of cells on a villus of the small intestine. To determine if dominant mutations resulting in the gain of staining--the induction of a Dlb-1b-like allele--could also be detected, we examined Dlb-1a...
Topics
- Animals
- Epithelium
- Ethylnitrosourea
- Genes, Dominant
- Heterozygote
- Homozygote
- Intestine, Small
- Mice
- Mice, Inbred Strains
- Mutagenesis
- Mutation
- Receptors, Mitogen