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Article

Phenotypic effects of heterozygosity for a BRCA2 mutation.

Human molecular genetics - 15 Oct 2003

Warren Madhuri, Lord Christopher J, Masabanda Julio, Griffin Darren, Ashworth Alan

Abstract excerpt

Heterozygous carriers of mutations in the BRCA2 gene have a high risk of developing breast and other cancers. In these individuals, BRCA2 appears to act as a tumour suppressor gene, in that loss of the wild type allele is frequently observed within tumours, leading to loss of BRCA2 function. Beca...

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Source

Identifiers

PMID: 12928478
DOI: 10.1093/hmg/ddg277

Genes

BRCA2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12928478-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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