Molecular and phenotypic characterization of a new mouse insertional mutation that causes a defect in the distal vertebrae of the spine.

doi:10.1093/genetics/140.3.1061

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Article

Molecular and phenotypic characterization of a new mouse insertional mutation that causes a defect in the distal vertebrae of the spine.

Genetics - 1 Jul 1995

Schrick J J, Dickinson M E, Hogan B L, Selby P B, Woychik R P

Abstract excerpt

We have identified and characterized the phenotype of a new insertional mutation in one line of transgenic mice. Mice carrying this mutation, which we have designated TgN(Imusd)370Rpw, display undulations of the vertebrae giving rise to a novel kinky-tail phenotype. Molecular characterization of the insertion site indicates that the transgene integration has occurred without any substantial alterations in the...

Topics

Actins
Aging
Animals
Animals, Newborn
Base Sequence
Chloramphenicol O-Acetyltransferase
Cloning, Molecular
Crosses, Genetic
Female
Homozygote
Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Transgenic

Molecular Sequence Data

Mutagenesis, Insertional

Phenotype

Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7672577
DOI: 10.1093/genetics/140.3.1061
PMCID: PMC1206661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7672577-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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