Article
The apolipoprotein epsilon 4 allele in Parkinson's disease with and without dementia.
Neurology - 1 Jul 1994
Marder K, Maestre G, Cote L, Mejia H, Alfaro B, Halim A, Tang M, Tycko B, Mayeux R
Abstract excerpt
The epsilon 4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer's disease (AD). Because dementia in AD and Parkinson's disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and for 44 age-matched healthy elderly controls from the same community. We hypothesized that if the...
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