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Article

Functional and molecular characterization of African swine fever virus mutants resistant to phosphonoacetic acid.

Virology - 1 Dec 1995

Marques M I, Costa J V

Abstract excerpt

African swine fever virus (ASFV) growth and plaque formation were inhibited by phosphonoacetic acid (PAA) concentrations of 200 micrograms/ml or more. One spontaneous mutant and two mutants isolated from mutagenized virus were resistant to PAA inhibition and showed practically normal viral DNA synthesis in the presence of PAA. DNA polymerase activity present in the cytoplasmic fraction from cells infected with...

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PMID: 8525640
DOI: 10.1006/viro.1995.9953

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