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O-2-Alkylated Cytosine Acyclic Nucleoside Phosphonamidate Prodrugs Display Pan-Genotype Antiviral Activity against African Swine Fever Virus.

mSphere - 21 Dec 2022

Goulding Leah V, Kiss Eleonóra, Vrancken Robert, Goris Nesya, Luo Min, Groaz Elisabetta, Herdewijn Piet, Dixon Linda

Abstract excerpt

African swine fever virus (ASFV) causes a highly contagious hemorrhagic disease with case fatality rates approaching 100% in domestic pigs. ASFV is responsible for substantial economic losses, but despite ongoing efforts, no vaccine or antiviral agent is currently available. Attempts to control the spread of ASFV are dependent on early detection, adherence to biosecurity measures, and culling of infected herds....

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Identifiers

PMID: 36317894
DOI: 10.1128/msphere.00378-22
PMCID: PMC9769911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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