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Article

African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages.

Journal of virology - 1 May 2006

Redrejo-Rodríguez Modesto, García-Escudero Ramón, Yáñez-Muñoz Rafael J, Salas María L, Salas José

Abstract excerpt

We show here that the African swine fever virus (ASFV) protein pE296R, predicted to be a class II apurinic/apyrimidinic (AP) endonuclease, possesses endonucleolytic activity specific for AP sites. Biochemical characterization of the purified recombinant enzyme indicated that the K(m) and catalytic efficiency values for the endonucleolytic reaction are in the range of those reported for Escherichia coli...

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Identifiers

PMID: 16641276
DOI: 10.1128/JVI.80.10.4847-4857.2006
PMCID: PMC1472066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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