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Isolation and characterization of TK-deficient mutants of African swine fever virus.

Virus research - 1 Apr 1995

Martín Hernández A M, Camacho A, Prieto J, Menéndez del Campo A M, Tabarés E

Abstract excerpt

African swine fever virus induces the synthesis of thymidine kinase (TK) in BHK TK-negative cells as an immediate early protein. The TK gene is not essential for growth of ASFV in cell culture and a stable viral strain deficient in TK has been isolated (E70NTKp). The genetic lesion of this ASFV TK- strain was identified by TK gene nucleotide sequencing, showing a nucleotide deletion leading to a -1 frameshift and...

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PMID: 7625127
DOI: 10.1016/0168-1702(94)00098-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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