Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain.

doi:10.1128/JVI.67.7.4323-4336.1993

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain.

Journal of virology - 1 Jul 1993

Taddie J A, Traktman P

Abstract excerpt

In this report, we describe the isolation, molecular genetic mapping, and phenotypic characterization of vaccinia virus mutants resistant to cytosine arabinoside (araC) and phosphonoacetic acid (PAA). At 37 degrees C, 8 microM araC was found to prevent macroscopic plaque formation by wild-type vi...

Topics

Animals
Aphidicolin
Base Sequence
Cell Line
Chlorocebus aethiops
Cytarabine
DNA-Directed DNA Polymerase
Drug Resistance
Exonucleases
In Vitro Techniques
L Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Nucleic Acid Synthesis Inhibitors

Oligodeoxyribonucleotides

Phosphonoacetic Acid

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 8389930
DOI: 10.1128/JVI.67.7.4323-4336.1993
PMCID: PMC237803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8389930-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain.PMID 8389930Read ↗

Genetic characterization of the vaccinia virus DNA polymerase: identification of point mutations conferring altered drug sensitivities and reduced fidelity.Semantic proximity Read ↗

Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs.Semantic proximity Read ↗

Functional and molecular characterization of African swine fever virus mutants resistant to phosphonoacetic acid.Semantic proximity Read ↗

A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivativesSemantic proximity Read ↗

A biological method for examining the effect of codon changes in a conserved region of DNA polymerase.Semantic proximity Read ↗

A single nucleotide substitution in the 5'-untranslated region of the vaccinia N2L gene is responsible for both alpha-amanitin-resistant and temperature-sensitive phenotypes.Semantic proximity Read ↗

Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains.Semantic proximity Read ↗

A targeted approach to identification of vaccinia virus postreplicative transcription elongation factors: genetic evidence for a role of the H5R gene in vaccinia transcription.Semantic proximity Read ↗

Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae.Semantic proximity Read ↗

Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene.Semantic proximity Read ↗

Isolation and characterization of cidofovir resistant vaccinia viruses.Semantic proximity Read ↗

A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.