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Retinoblastoma Protein Paralogs and Tumor Suppression

18 Mar 2022

Abstract excerpt

The retinoblastoma susceptibility gene (RB1) is the first tumor suppressor gene discovered and a prototype for understanding regulatory networks that function in opposition to oncogenic stimuli. More than 3 decades of research has firmly established a widespread and prominent role for RB1 in human cancer. Yet, this gene encodes but one of three structurally and functionally related proteins that comprise the...

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PMID: 35368709
DOI: 10.3389/fgene.2022.818719

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