Article
Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila.
Neuron - 1 Sept 1995
Broadie K, Prokop A, Bellen H J, O'Kane C J, Schulze K L, Sweeney S T
Abstract excerpt
In synaptic transmission, vesicles are proposed to dock at presynaptic active zones by the association of synaptobrevin (v-SNARE) with syntaxin (t-SNARE). We test this hypothesis in Drosophila strains lacking neural synaptobrevin (n-synaptobrevin) or syntaxin. We showed previously that loss of either protein completely blocks synaptic transmission. Here, we attempt to establish the level of this blockade....
Topics
- Animals
- Animals, Genetically Modified
- Binding Sites
- Black Widow Spider
- Calcium
- Drosophila
- Membrane Fusion
- Membrane Proteins
- Mutation
- Nerve Tissue Proteins
- Qa-SNARE Proteins