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Article

Role of the mitochondrial DnaJ homologue, Mdj1p, in the prevention of heat-induced protein aggregation.

FEBS letters - 12 Feb 1996

Prip-Buus C, Westerman B, Schmitt M, Langer T, Neupert W, Schwarz E

Abstract excerpt

The role of the mitochondrial Hsp70 system in the prevention of heat-induced protein aggregation was studied in isolated mitochondria from Saccharomyces cerevisiae. Firefly luciferase was employed as a thermolabile tester protein. After shift to 40 degrees Celsius transient increase of mt-Hsp70/l...

Topics

Bacterial Proteins
Carrier Proteins
Fungal Proteins
HSP40 Heat-Shock Proteins
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Heat-Shock Response
Luciferases
Membrane Proteins
Membrane Transport Proteins
Mitochondria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitochondrial Membrane Transport Proteins

Molecular Chaperones

Mutation

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 8603724
DOI: 10.1016/0014-5793(96)00049-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8603724-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Role of the mitochondrial DnaJ homologue, Mdj1p, in the prevention of heat-induced protein aggregation.PMID 8603724Read ↗

Role of the mitochondrial DnaJ homolog Mdj1p as a chaperone for mitochondrially synthesized and imported proteins.Semantic proximity Read ↗

Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function.Semantic proximity Read ↗

The disaggregation activity of the mitochondrial ClpB homolog Hsp78 maintains Hsp70 function during heat stress.Semantic proximity Read ↗

A role for a eukaryotic GrpE-related protein, Mge1p, in protein translocation.Semantic proximity Read ↗

Hsp70 chaperone machine remodels protein aggregates at the initial step of Hsp70-Hsp100-dependent disaggregation.Semantic proximity Read ↗

Functional specificity of the mitochondrial DnaJ protein, Mdj1p, in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mitochondrial GrpE modulates the function of matrix Hsp70 in translocation and maturation of preproteins.Semantic proximity Read ↗

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Probing the different chaperone activities of the bacterial HSP70-HSP40 system using a thermolabile luciferase substrate.Semantic proximity Read ↗

Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation.Semantic proximity Read ↗

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.Semantic proximity Read ↗

Interaction between the nucleotide exchange factor Mge1 and the mitochondrial Hsp70 Ssc1.Semantic proximity Read ↗

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