Article
Inactivation of the mitochondrial heat shock protein zim17 leads to aggregation of matrix hsp70s followed by pleiotropic effects on morphology and protein biogenesis.
Journal of molecular biology - 5 Aug 2005
Sanjuán Szklarz Luiza K, Guiard Bernard, Rissler Michael, Wiedemann Nils, Kozjak Vera, van der Laan Martin, Lohaus Christiane, Marcus Katrin, Meyer Helmut E, Chacinska Agnieszka, Pfanner Nikolaus, Meisinger Chris
Abstract excerpt
The biogenesis of mitochondrial matrix proteins involves the translocase of the outer membrane, the presequence translocase of the inner membrane and the presequence translocase-associated motor. The mitochondrial heat shock protein 70 (mtHsp70) forms the central core of the motor. Recent studies led to the identification of Zim17, a mitochondrial zinc finger motif protein that interacts with mtHsp70. Different...
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