Article
The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import.
The EMBO journal - 1 Nov 1996
Schneider H C, Westermann B, Neupert W, Brunner M
Abstract excerpt
Import of preproteins into the mitochondrial matrix is driven by the ATP-dependent interaction of mt-Hsp70 with the peripheral inner membrane import protein Tim44 and the preprotein in transit. We show that Mge1p, a co-chaperone of mt-Hsp70, plays a key role in the ATP-dependent import reaction c...
Topics
- Adenosine Triphosphate
- Biological Transport, Active
- Carrier Proteins
- Cations, Monovalent
- Escherichia coli
- Fungal Proteins
- HSP70 Heat-Shock Proteins
- Heat-Shock Proteins
- Macromolecular Substances
- Membrane Proteins
- Membrane Transport Proteins
- Mitochondria
- Mitochondrial Membrane Transport Proteins
- Mitochondrial Precursor Protein Import Complex Proteins