Article
Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function.
Molecular biology of the cell - 1 Mar 2013
Marada Adinarayana, Allu Praveen Kumar, Murari Anjaneyulu, PullaReddy BhoomiReddy, Tammineni Prasad, Thiriveedi Venkata Ramana, Danduprolu Jayasree, Sepuri Naresh Babu V
Abstract excerpt
Despite the growing evidence of the role of oxidative stress in disease, its molecular mechanism of action remains poorly understood. The yeast Saccharomyces cerevisiae provides a valuable model system in which to elucidate the effects of oxidative stress on mitochondria in higher eukaryotes. Dimeric yeast Mge1, the cochaperone of heat shock protein 70 (Hsp70), is essential for exchanging ATP for ADP on Hsp70 and...
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