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Article

PLP/DM20 expression and turnover in a transgenic mouse model of Pelizaeus-Merzbacher disease.

Glia - 1 Nov 2010

Karim Saadia A, Barrie Jennifer A, McCulloch Mailis C, Montague Paul, Edgar Julia M, Iden Debrah L, Anderson Thomas J, Nave Klaus-Armin, Griffiths Ian R, McLaughlin Mark

Abstract excerpt

The most common cause of Pelizaeus-Merzbacher (PMD) is due to duplication of the PLP1 gene but it is unclear how increased gene dosage affects PLP turnover and causes dysmyelination. We have studied the dynamics of PLP/DM20 in a transgenic mouse model of PMD with increased gene dosage of the proteolipid protein gene (Plp1). The turnover of PLP/DM20 were investigated using an ex-vivo brain slice system and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20629189
DOI: 10.1002/glia.21043

Genes

MBP
PLP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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PLP/DM20 expression and turnover in a transgenic mouse model of Pelizaeus-Merzbacher disease.PMID 20629189Read ↗

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